 ผลงานตีพิมพ์ในวารสารวิชาการIn vitro Efficacy of the Antifungal Activity of Some Thai Medicinal-Plants on the Pathogenic Fungus, Saprolegnia parasitica H2, from Fishผู้แต่ง: Dr.Pareeya Udomkusonsri, Associate Professor , Dr.Kamolchai Trongvanichnam, Associate Professor , Ms.Malinee Limpoka, Professor ,  Narumol Klangkaew, Napasorn Kusucharit, วารสาร: |
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 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Pharmacokinetics of Enrofloxacin in Koi Carp (Cyprinus carpio) after Various Routes of Administration) ผู้เขียน:ดร.ปารียา อุดมกุศลศรี, รองศาสตราจารย์, Surapong Arthitvong, นฤมล กลางแก้ว, Napasorn Kusucharit สื่อสิ่งพิมพ์:pdf AbstractThe pharmacokinetics of enrofloxacin was studied in koi carp (Cyprinus carpio) after single administration by intraperitoneal (IP) and intramuscular (IM) injection, oral gavage (PO) at a dose of 10 mg/kg body weight and by 5 mg/liter bath for 5 hr at room temperature (27?C). Blood samples were obtained from caudal vein at 0, 15, 30, 60 min and 2, 8, 24, 48, 72 and 96 hr following administration. Serum antimicrobial concentrations were determined by microbioassay using Bacillus subtilis as an indicator organism where maximal concentrations (Cmax) of drug in plasma were 36.6 ? 21.3, 4.6 ? 2.4, 14.4 ? 7.7 and 0.9 ? 0.3 mg/L after IP, IM, PO and bath at 60, 60, 5 and 5 min, respectively. According to one-compartment pharmacokinetic model, elimination half-life ( T1 2 ) were 16.1, 17.9, 16.6 and 42.1 hr, volumes of distribution (Vd) were 0.3, 3.1, 1.5 and 10.4 L/kg, and area under the curve (AUC) were 797.8, 82.7, 156.4 and 29.1 mg-hr/L after IP, IM, PO and bath, respectively. It was found that those 4 routes of enrofloxacin administration to koi were effective since the concentrations of drug in plasma were greater than minimal inhibitory concentration (MIC) of most fish bacterial pathogens. |
หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : In vitro Efficacy of the Antifungal Activity of Some Thai Medicinal-Plants on the Pathogenic Fungus, Saprolegnia parasitica H2, from Fish) ผู้เขียน:ดร.ปารียา อุดมกุศลศรี, รองศาสตราจารย์, ดร.กมลชัย ตรงวานิชนาม, รองศาสตราจารย์, นางสาวมาลินี ลิ้มโภคา, ศาสตราจารย์, นฤมล กลางแก้ว, Napasorn Kusucharit สื่อสิ่งพิมพ์:pdf AbstractEthanol crude extracts of galanga (Alpinia galanga) (rhizome), betel vine (Piper betel Linn.) (leaves), Rhinacanthus nasutus Linn. (leaves), Kaempferia galanga Linn. (leaves and roots) were studied for fungistatic and fungicidal activity against water mold Saprolignea parasitica H2. Minimal inhibitory concentration (MIC) of crude extracts of betel vine leaves and K. galanga Linn. roots against S. parasitica H2 were 500 and 125 ?g/ml, respectively. The crude of R. nasutus Linn. leaves at 500 ?g/ml could inhibit fungal growth for 46%. The crude extracts of galanga rhizome and K. galanga leaves at 500 ?g/ ml had minimal fungistatic activity against S. parasitica H2. The fungicidal concentrations of crude extracts of betel vine leaves, R. nasutus Linn. leaves and K. galanga Linn. leaves against S. parasitica H2 were 500 ?g/ml after 24 hr-immersion, 5,000 ?g/ml after 24 hr-immersion and 50 ?g/ml after 120 min-immersion, respectively. Crude extracts of galanga rhizome and K. galanga Linn. leaves at 5,000 ?g/ml had no fungicidal effects in this study. In addition, the fungicidal activity varied between concentration of plant extract and exposure time. This study presented that the crude extracts from betel vine leaves and K. galanga Linn. roots had high antifungal activity against S. parasitica H2, while R. nasutus Linn. leaves had moderate activity. |
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